Peter Russel is a sixty year old retired banking executive who lost a portion of his jaw to a benign tumor. Due to the skill and expertise of Dr. Cameron Clokie he has regrown seven centimeters of bone. He is one of eight Canadian patients who have undergone a type of bone regeneration changing reconstructive surgery.
Dr. Cameron Clokie practices at the University of Toronto and heads oral and maxillofacial surgery. His new techniques allows bones to grow in the same fashion as in a new baby. The procedure is a milestone in tissue regeneration and researchers are seeing their dream come to life.
Dr, Clokie presented cases in regenerative medicine at a U of T conference and the fact Mr. Russel’s operation only took four hours was amazing. The fact he was skiing two weeks later was astounding. The jaw reconstruction involved the forming of a putty-like gel from a growth protein. Read more: Our Team – Induce Biologics
It was modeled after the missing section Mr. Russel’s jaw shape. With the support of an implanted titanium rod the model was placed into the missing section. After five days blood cells were growing over the model and the gel started to dissolve. The jawbone started growing and closed off the gap.
The technique is effective but incredibly expensive. The protein used comes at a price of $6,000 and is not covered by Medicare. Mr. Russel was lucky to be able to afford the procedure. The protein is called bone morphogenetic protein and also referred to as BMP.
Marshall Urist made the discovery in the 1950’s at the University of California. He spent four years working with Dr. Cameron Clokie and passed away in 2001. The most famous current use was countering bone loss around Dionne Warwick’s teeth. Learn more about Cameron Clokie: https://www.yellowpages.ca/bus/Ontario/Toronto/Dr-Cameron-Clokie/390278.html and https://www.dentevents.com/speaker-profile/dr-cameron–clokie/c12024915
Towards the end of the 1990’s Dr. Clokie wanted BMP tested as a tool for reconstructive jaw surgery. He discovered how much bone was required to make BMP. It took the leg and arm bones of forty cadavers to yield three milligrams. He eventually turned to a U.S. biotech firm capable of producing BMP using the cells in Chinese hamsters. Since then he has been able to perform the procedure on eight patients.